Methylamine → HCID 10561620, compound

HRID 654063Notes

Reaction equation

HRID 654063 reaction equation
[CH3:1][NH2:2].O[CH:4]1[NH:10][C:9](=[O:11])[C:8]2[S:12][CH:13]=[CH:14][C:7]=2[N:6]2[CH:15]=[CH:16][CH:17]=[C:5]12>O>[CH3:1][NH:2][CH:4]1[NH:10][C:9](=[O:11])[C:8]2[S:12][CH:13]=[CH:14][C:7]=2[N:6]2[CH:15]=[CH:16][CH:17]=[C:5]12

Participants

4

Reactant 2

HCID 6329MethylamineHCID 98592896-hydroxy-5,6-dihydro-4-oxo-4H-pyrrolo[1,2-a]thieno[2,3-f][1,4]diazepine

Product 1

HCID 10561620HCID 10561620, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3 ml of 35% aqueous solution of methylamine are added in a single portion to a suspension of 1.1 g (0.005 mol) of 6-hydroxy-5,6-dihydro-4-oxo-4H-pyrrolo -[1,2-a]thieno[2,3-f][1,4]diazepine in 20 ml of water, and the reaction mixture is then stirred for 4 hours at room temperature The product is gradually solubilized and then reprecipitates The precipitate is drained, washed with water, dried and recrystallized. 0.7 g of 6-methylamino-5,6-dihydro-4-oxo-4H -pyrrolo[1,2-a]thieno[2,3-f][1,4]diazepine is obtained in the form of white crystals, melting point 146° C. (ethyl ether).

Workup

  1. customreprecipitates The precipitate
  2. washwashed with water
  3. customdried
  4. customrecrystallized

Sources & evidence

ORD record
ord-4c733d1060ea4bc79fed39b9447e85f1
Source dataset
uspto-grants-1992_07
Patent number
US05130301

Reaction notes

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