反应详情

3 ml of 35% aqueous solution of methylamine are added in a single portion to a suspension of 1.1 g (0.005 mol) of 6-hydroxy-5,6-dihydro-4-oxo-4H-pyrrolo -[1,2-a]thieno[2,3-f][1,4]diazepine in 20 ml of water, and the reaction mixture is then stirred for 4 hours at room temperature The product is gradually solubilized and then reprecipitates The precipitate is drained, washed with water, dried and recrystallized. 0.7 g of 6-methylamino-5,6-dihydro-4-oxo-4H -pyrrolo[1,2-a]thieno[2,3-f][1,4]diazepine is obtained in the form of white crystals, melting point 146° C. (ethyl ether).

1. customreprecipitates The precipitate
2. washwashed with water
3. customdried
4. customrecrystallized