Ethyl Acetoacetate → HCID 10640319, compound

HRID 654066Notes

Reaction equation

HRID 654066 reaction equation
O[CH:2]1[NH:8][C:7](=[O:9])[C:6]2[S:10][CH:11]=[CH:12][C:5]=2[N:4]2[CH:13]=[CH:14][CH:15]=[C:3]12.[C:16]([O:22][CH2:23][CH3:24])(=[O:21])[CH2:17][C:18]([CH3:20])=[O:19]>C(OCC)C>[CH2:23]([O:22][C:16]([CH:17]([CH:2]1[NH:8][C:7](=[O:9])[C:6]2[S:10][CH:11]=[CH:12][C:5]=2[N:4]2[CH:13]=[CH:14][CH:15]=[C:3]12)[C:18]([CH3:20])=[O:19])=[O:21])[CH3:24]

Participants

4

Reactant 2

HCID 8868Ethyl AcetoacetateHCID 98592896-hydroxy-5,6-dihydro-4-oxo-4H-pyrrolo[1,2-a]thieno[2,3-f][1,4]diazepine

Product 1

HCID 10640319HCID 10640319, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Using the procedure described in Example 26, starting with 1 g of 6-hydroxy-5,6-dihydro-4-oxo-4H -pyrrolo[1,2-a]thieno[2,3-f][1,4]diazepine and 2 ml of ethyl acetoacetate, 0.7 g of 6-[1-(ethoxycarbonyl) -acetonyl]-5,6-dihydro-4-oxo-4H-pyrrolo[1,2-a]thieno -[2,3-f][1,4]diazepine was obtained in the form of white crystals, melting point 196° C. (ethyl ether).

Sources & evidence

ORD record
ord-ab2faff14e9a4f3db48c95e88f7e5df3
Source dataset
uspto-grants-1992_07
Patent number
US05130301

Reaction notes

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