反应详情

A solution of 4-bromo-1-(chloromethyl)-2-(p-chlorophenyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile (2.0 g, 0.005 mol) in absolute ethanol is treated with a 21% wt/wt ethanolic solution of sodium ethoxide (0.36 g, 0.0053 mol), heated to 75°-80° C. for 20-30 minutes, cooled to room temperature and diluted with water and ether. The organic phase is dried over anhydrous magnesium sulfate and concentrated in vacuo to give a solid which is recrystallized form heptane to give the title product as a white solid (1.75 g, mp 97°-98° C.).

1. temperatureheated to 75°-80° C. for 20-30 minutes
2. dry with materialThe organic phase is dried over anhydrous magnesium sulfate
3. concentrationconcentrated in vacuo
4. customto give a solid which
5. customis recrystallized form heptane