Hydrogen Bromide → HCID 67746805, compound

HRID 654169Notes

Reaction equation

HRID 654169 reaction equation
C(OC([NH:11][C@H:12]1[CH2:16][N:15]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C@H:14](/[CH:24]=[CH:25]\[CH2:26][CH2:27][CH2:28][C:29]([O:31][CH3:32])=[O:30])[CH2:13]1)=O)C1C=CC=CC=1.[BrH:33]>C(O)(=O)C>[BrH:33].[NH2:11][C@H:12]1[CH2:16][N:15]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C@H:14](/[CH:24]=[CH:25]\[CH2:26][CH2:27][CH2:28][C:29]([O:31][CH3:32])=[O:30])[CH2:13]1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 15670483HCID 15670483, compound

Product 1

HCID 67746805HCID 67746805, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of (2S,4R)-4-benzyloxycarbonylamino-2-[(Z)-5-methoxycarbonyl-1-pentenyl]-1-(phenylmethyl)pyrrolidine (700 mg) and 30% hydrogen bromide in acetic acid (2 ml) was stirred at room temperature for 2 hours and the solvent was evaporated in vacuo to give (2S,4R)-4-amino-2-[(Z)-5-methoxycarbonyl-1-pentenyl]-1(phenylmethyl)pyrrolidine hydrobromide 800 mg) as an oil.

Workup

  1. customthe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-a3c2727c19eb4fa8ab89e9e71bcc9e8f
Source dataset
uspto-grants-1992_07
Patent number
US05130323

Reaction notes

Loading…