3-Fluoro-1,2-propanediol → HCID 19888726, compound
Reaction equation
[F:1][CH2:2][CH:3]([CH2:7][CH:8]([F:10])[F:9])[CH:4]([F:6])[F:5].FCC(O)CO>>[F:1][CH2:2][C:3]([CH:7]=[C:8]([F:10])[F:9])=[C:4]([F:6])[F:5]Participants
3
Procedure
As another example, 2-methyl-1,1,3-trifluoropropane may be prepared by reacting commercially available fluoroacetone with a CF2 carbene to form 2-fluoromethyl-1,1-difluoro-1-propene which may then be hydrogenated to form 2-methyl-1,1,3-trifluoropropane. As another example, 2-fluoromethyl-1,1,4,4-tetrafluorobutane may be prepared by oxidizing commercially available 3-fluoro-1,2-propanediol to form a product which may then be reacted with a CF2 carbene to form 2-fluoromethyl-1,1,4,4-tetrafluoro-1,3-butadiene; the 2-fluoromethyl-1,1,4,4-tetrafluoro-1,3-butadiene may then be hydrogenated to form 2-fluoromethyl-1,1,4,4-tetrafluorobutane.
Workup
- customto form a product which
Sources & evidence
- ORD record
- ord-4f58982255a7402383a7d111a9360a2b
- Source dataset
- uspto-grants-1992_07
- Patent number
- US05130345
Reaction notes
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