3-Fluoro-1,2-propanediol → HCID 19888726, compound

Participants

Reaction Steps

As another example, 2-methyl-1,1,3-trifluoropropane may be prepared by reacting commercially available fluoroacetone with a CF2 carbene to form 2-fluoromethyl-1,1-difluoro-1-propene which may then be hydrogenated to form 2-methyl-1,1,3-trifluoropropane. As another example, 2-fluoromethyl-1,1,4,4-tetrafluorobutane may be prepared by oxidizing commercially available 3-fluoro-1,2-propanediol to form a product which may then be reacted with a CF2 carbene to form 2-fluoromethyl-1,1,4,4-tetrafluoro-1,3-butadiene; the 2-fluoromethyl-1,1,4,4-tetrafluoro-1,3-butadiene may then be hydrogenated to form 2-fluoromethyl-1,1,4,4-tetrafluorobutane.

Provenance & Evidence