Hydrochloric Acid → HCID 14456701, compound

HRID 654251Notes

Reaction equation

HRID 654251 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH:11](Br)[C:12]([OH:14])=O)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[NH2:16][C:17](N)=[S:18].Cl.S1(CCCC1)(=O)=[O:22]>O>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH:11]2[S:18][C:17](=[O:22])[NH:16][C:12]2=[O:14])=[CH:8][CH:9]=1)(=[O:3])[CH3:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 31347SulfolaneHCID 2652713-(4-acetylphenyl)-2-bromopropanoic acidHCID 2723790Thiourea

Product 1

HCID 14456701HCID 14456701, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 3-(4-acetylphenyl)-2-bromopropanoic acid (87 g, 0.32 mol, prepared according to Cleland, Org. Synth. vol. 51, p. 1, 1971), and thiourea (48.7 g, 0.64 mol) in sulfolane (100 mL) was heated to 105°-110° C. for 5 hours. To this mixture was added a 2N HCl solution (162 mL) and the resulting solution was heated to 105°-110° C. overnight. After cooling and diluting with water, present title product was collected, washed with water and dried (75 g, 94%); mp 171°-172° C.

Workup

  1. temperaturethe resulting solution was heated to 105°-110° C. overnight
  2. temperatureAfter cooling

Sources & evidence

ORD record
ord-2b51b59555d54f58aa65fcab5fe7893a
Source dataset
uspto-grants-1992_07
Patent number
US05130379

Reaction notes

Loading…