Hydrochloric Acid → HCID 15538104, compound

HRID 654272Notes

Reaction equation

HRID 654272 reaction equation
[N+:1]([C:4]1[CH:14]=[C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:12]=[CH:11][C:5]=1[C:6]([O:8]CC)=[O:7])([O-:3])=[O:2].[OH-].[Na+].Cl>C(O)C>[CH2:18]([O:17][C:15](=[O:16])[C:13]1[CH:12]=[CH:11][C:5]([C:6]([OH:8])=[O:7])=[C:4]([N+:1]([O-:3])=[O:2])[CH:14]=1)[CH3:19]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13609179HCID 13609179, compound

Product 1

HCID 15538104HCID 15538104, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of Diethyl nitroterephthalate (17.9 g) in 300 mL ethanol was added 1N NaOH (70 mL) and stirred overnight. 1N HCl (70 mL) was added and the reaction was partitioned between methylene chloride (200 mL) and water (200 mL). The aqueous layer was extracted an additional three times. The combined organic extracts were dried and the solvent removed in vacuo to afford Ethyl-3-nitro-4-carboxybenzoate as a white solid.

Workup

  1. customthe reaction was partitioned between methylene chloride (200 mL) and water (200 mL)
  2. extractionThe aqueous layer was extracted an additional three times
  3. customThe combined organic extracts were dried
  4. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-27ba7dddb22649b99903d8af43f53164
Source dataset
uspto-grants-1992_07
Patent number
US05130430

Reaction notes

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