P-Xylene → HCID 11322527, compound

HRID 654284Notes

Reaction equation

HRID 654284 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:11][C:12]1[CH:13]=[CH:14][C:15]([CH3:18])=[CH:16][CH:17]=1>>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([C:17]1[CH:16]=[C:15]([CH3:18])[CH:14]=[CH:13][C:12]=1[CH3:11])=[O:6]

Participants

3

Reactant 2

HCID 7809P-XyleneHCID 83742-Chlorobenzoic Acid

Product 1

HCID 11322527HCID 11322527, compoundYield 55%

Procedure

The HF-catalyzed condensation of 2-chlorobenzoic acid with p-xylene was also investigated. Condensation was carried out at 60° C. for 4.5 hours. 2-chloro-2',5'-dimethylbenzophenone product was isolated in 55% yield. Upon repeating the reaction at 80° C. for 4.5 hours, the conversion was slightly increased to afford the product in 60% yield. The results appear to show that p-xylene is not as reactive as m-xylene in this reaction.

Workup

  1. customCondensation

Sources & evidence

ORD record
ord-54fa5519371148088416e2a4af0effef
Source dataset
uspto-grants-1992_07
Patent number
US05130448

Reaction notes

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