Ethyl Acetate → HCID 10088309, 화합물

HRID 654310노트

반응식

HRID 654310 반응식
[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C@@H:10]([O:17]C1CCCCO1)/[CH:11]=[CH:12]/[C:13]([O:15][CH3:16])=[O:14])=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OCC)(=O)C>CCCCCC>[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[C@@H:10]([OH:17])/[CH:11]=[CH:12]/[C:13]([O:15][CH3:16])=[O:14])=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 8857Ethyl AcetateHCID 131717463HCID 131717463, 화합물

생성물 1

HCID 10088309HCID 10088309, 화합물수율 75%

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

Using the procedure of Example 6 with the resultant compound of Example 12 provided, following silica gel chromatography using a gradient of 15-30% ethyl acetate in hexane, the desired compound (m.p. 108°-109° C., Rf 0.44, 2:1 hexane:ethyl acetate) in 75% yield. 1H NMR (CDCl3) 1.39 (s, 9 H), 2.96 (d, J=8 Hz, 2 H), 3.73 (s, 3 H), 3.75-3.85 (m, 2 H), 4.32 (br, 1 H), 4.79 (br d, 1 H), 6.11 (br d, J=15 Hz, 1 H), 6.94 (dd, J=15, 4 Hz, 1 H), 7.2-7.35 (m, 5 H). Mass spectrum: (M+H)+ =336.

후처리

  1. customprovided

출처 및 근거

ORD 기록
ord-b716aa9137634457b8c99b22251a1650
출처 데이터셋
uspto-grants-1992_07
특허 번호
US05130468

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