Ethyl Acetate → HCID 10088309, compound

Participants

Reaction Steps

Using the procedure of Example 6 with the resultant compound of Example 12 provided, following silica gel chromatography using a gradient of 15-30% ethyl acetate in hexane, the desired compound (m.p. 108°-109° C., Rf 0.44, 2:1 hexane:ethyl acetate) in 75% yield. 1H NMR (CDCl3) 1.39 (s, 9 H), 2.96 (d, J=8 Hz, 2 H), 3.73 (s, 3 H), 3.75-3.85 (m, 2 H), 4.32 (br, 1 H), 4.79 (br d, 1 H), 6.11 (br d, J=15 Hz, 1 H), 6.94 (dd, J=15, 4 Hz, 1 H), 7.2-7.35 (m, 5 H). Mass spectrum: (M+H)+ =336.

Provenance & Evidence