反应详情

8 ml of a tetra-n-butylammonium fluoride/THF solution which has been prepared from 5 g of tetra-n-butylammonium fluoride trihydrate by drying at 60°/0.1 torr and making up to 20.0 ml with tetrahydrofuran is added to a solution of 201 mg (0.757 mmol) of N-allyl-N-phenylsulphonylmethyl-(R)-glycidic acid amide in 1 ml of tetrahydrofuran. The resulting reaction mixture is stirred for 2 hours at 0° and then partitioned between methylene chloride and phosphate buffer solution having a pH of 8.0. The crude product isolated from the organic layer by means of concentration by evaporation is chromatographed over preparative silica gel plates in ethyl acetate/hexane (2:1) and the title compound is obtained in the form of a colourless oil.

1. customby drying at 60°/0.1 torr
2. customThe resulting reaction mixture
3. custompartitioned between methylene chloride and phosphate buffer solution
4. customThe crude product isolated from the organic layer by means of concentration by evaporation
5. customis chromatographed over preparative silica gel plates in ethyl acetate/hexane (2:1)