HCID 15171352, compound → HCID 17799081, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 36, but starting from 4-[(3-chloro-2'-(2-tributylstannyl-2H-tetrazol-5-yl)biphenyl-4-yl)methoxy]-2-ethyl-5,6,7,8-tetrahydroquinoline [prepared as a solution in xylene using a similar procedure to that described in Example 36 but starting from 4-[(3-chloro-2'-cyanobiphenyl-4-yl)methoxy]-2-ethyl-5,6,7,8-tetrahydroquinoline (A)], there was obtained in 60% yield 2-ethyl-4-(3-chloro-2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methoxy]-5,6,7,8-tetrahydroquinoline hydrochloride, m.p. 194°-197° C.; NMR (d6 -DMSO): 1.3(t,3H), 1.75-1.85(m,4H), 2.6-2.7(m,2H), 2.9-3.05(m,4H), 5.5(s,2H), 7.35-7.75 (complex m,7H), 7.85-7.95(m,1H); mass spectrum (+ve FAB, DMSO/m-nitrobenzyl alcohol): 416 (M+H)+ ; microanalysis, found: C,61.7; H,5.5; N,14.1%; C25H24ClN5O.HCl requires: C,62.2; H, .2; N,14.5%.

Provenance & Evidence