HCID 15171352, compound → HCID 17799081, compound

HRID 654369Notes

Reaction equation

HRID 654369 reaction equation
[Cl:1]C1C=C(C2C=CC=CC=2C2N=NN([Sn](CCCC)(CCCC)CCCC)N=2)C=CC=1CO[C:10]1[C:19]2[CH2:18][CH2:17][CH2:16][CH2:15][C:14]=2[N:13]=[C:12](CC)[CH:11]=1.FC(F)(F)C1C=C(OCC2C=CC(C3C=CC=CC=3C3N=NN(C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)N=3)=CC=2)C2CCCCC=2N=1>C1(C)C(C)=CC=CC=1>[ClH:1].[N:13]1[C:14]2[CH2:15][CH2:16][CH2:17][CH2:18][C:19]=2[CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 15171352HCID 15171352, compoundHCID 19771817HCID 19771817, compound

Product 1

HCID 17799081HCID 17799081, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

Using an analogous procedure to that described in Example 36, but starting from 4-[(3-chloro-2'-(2-tributylstannyl-2H-tetrazol-5-yl)biphenyl-4-yl)methoxy]-2-ethyl-5,6,7,8-tetrahydroquinoline [prepared as a solution in xylene using a similar procedure to that described in Example 36 but starting from 4-[(3-chloro-2'-cyanobiphenyl-4-yl)methoxy]-2-ethyl-5,6,7,8-tetrahydroquinoline (A)], there was obtained in 60% yield 2-ethyl-4-(3-chloro-2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methoxy]-5,6,7,8-tetrahydroquinoline hydrochloride, m.p. 194°-197° C.; NMR (d6 -DMSO): 1.3(t,3H), 1.75-1.85(m,4H), 2.6-2.7(m,2H), 2.9-3.05(m,4H), 5.5(s,2H), 7.35-7.75 (complex m,7H), 7.85-7.95(m,1H); mass spectrum (+ve FAB, DMSO/m-nitrobenzyl alcohol): 416 (M+H)+ ; microanalysis, found: C,61.7; H,5.5; N,14.1%; C25H24ClN5O.HCl requires: C,62.2; H, .2; N,14.5%.

Sources & evidence

ORD record
ord-b760bd2baeda4d178215c91bdc7def8a
Source dataset
uspto-grants-1992_07
Patent number
US05130318

Reaction notes

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