Sodium Hydroxide → Benzenamine, 2-chloro-N-(hexahydro-3H-thiazolo[3,4-a]pyridin-3-ylidene)-

Participants

Reaction Steps

1 g 1-(2-Chlorophenylthiocarbamoyl)-2-hydroxymethylpiperidine in 20 ml 48% hydrobromic acid was heated under reflux for 2 hours. The mixture was then neutralised under cooling with 2N caustic soda, extracted with methylene chloride, the extracts dried over magnesium sulphate and the solvent distilled. The residue was recrystallised from diisopropyl ether.

Provenance & Evidence