反应详情

1 g 1-(2-Chlorophenylthiocarbamoyl)-2-hydroxymethylpiperidine in 20 ml 48% hydrobromic acid was heated under reflux for 2 hours. The mixture was then neutralised under cooling with 2N caustic soda, extracted with methylene chloride, the extracts dried over magnesium sulphate and the solvent distilled. The residue was recrystallised from diisopropyl ether.

1. temperatureunder reflux for 2 hours
2. extractionextracted with methylene chloride
3. dry with materialthe extracts dried over magnesium sulphate
4. distillationthe solvent distilled
5. customThe residue was recrystallised from diisopropyl ether