Hydrochloric Acid → HCID 14441900, compound

HRID 654403Notes

Reaction equation

HRID 654403 reaction equation
[Cl:1][C:2]1[C:7]([O:8]S(C)(=O)=O)=[CH:6][C:5]([N:13]=[C:14]2[N:18]3[CH2:19][CH2:20][CH2:21][CH:17]3[CH2:16][S:15]2)=[C:4]([F:22])[CH:3]=1.[OH-].[Na+].Cl>C(O)C>[Cl:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:13]=[C:14]2[N:18]3[CH2:19][CH2:20][CH2:21][CH:17]3[CH2:16][S:15]2)=[C:4]([F:22])[CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14441886HCID 14441886, compound

Product 1

HCID 14441900HCID 14441900, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
40 °C

Procedure

22 g 3-(4-Chloro-2-fluoro-5-methylsulphonyloxyphenylimino)-tetrahydro-1H,3H-pyrrolo[1,2-c]thiazole in 400 ml ethanol was treated with 400 ml 2 N caustic soda and stirred at 40° C. for 4 hours. With ice cooling it was then neutralised with 10% hydrochloric acid and extracted with methylene chloride. After drying over magnesium sulphate and concentrating, the residue was recrystallised from isopropanol.

Workup

  1. extractionextracted with methylene chloride
  2. dry with materialAfter drying over magnesium sulphate
  3. concentrationconcentrating
  4. customthe residue was recrystallised from isopropanol

Sources & evidence

ORD record
ord-9bc24360fe6241d6a62bb299bf409f1b
Source dataset
uspto-grants-1992_07
Patent number
US05131946

Reaction notes

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