1,3-Dimethyl-2-imidazolidinone → HCID 19887194, compound

HRID 654407Notes

Reaction equation

HRID 654407 reaction equation
[CH2:1]([CH:3]1[CH2:7][N:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[C:5](=[O:18])[CH:4]1[C:19]1[CH:24]=[CH:23][CH:22]=[C:21](Br)[CH:20]=1)[CH3:2].[CH3:26][N:27]1CCN(C)C1=O>>[CH2:1]([CH:3]1[CH2:7][N:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[C:5](=[O:18])[CH:4]1[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([C:26]#[N:27])[CH:20]=1)[CH3:2]

Participants

3

Reactant 2

HCID 66611,3-Dimethyl-2-imidazolidinoneHCID 19887186HCID 19887186, compound

Product 1

HCID 19887194HCID 19887194, compound

Procedure

To 10 ml of 1,3-dimethyl-2-imidazolidinone, 0.7 g of 4-ethyl-3-(3-bromophenyl)-1-(3-trifluoromethylphenyl)-2-pyrrolidinone (Compound No. 25) and 1.2 g of cuprous cyanide were added. After the resultant mixture was stirred at 160° C. for 4 hours, the insoluble matter was filtered off from the reaction mixture and the filtrate was poured into water, followed by extraction with toluene. The extract was dried over anhydrous sodium sulfate, concentrated in an evaporator, and then purified by chromatography on a silica gel column, whereby 0.35 g of the title compound was obtained.

Workup

  1. filtrationthe insoluble matter was filtered off from the reaction mixture
  2. additionthe filtrate was poured into water
  3. extractionfollowed by extraction with toluene
  4. dry with materialThe extract was dried over anhydrous sodium sulfate
  5. concentrationconcentrated in an evaporator
  6. custompurified by chromatography on a silica gel column

Sources & evidence

ORD record
ord-af670f5484594af29cadf1cc16a8fdb6
Source dataset
uspto-grants-1992_07
Patent number
US05131947

Reaction notes

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