1,3-Dimethyl-2-imidazolidinone → HCID 19887194, compound

Participants

Reaction Steps

To 10 ml of 1,3-dimethyl-2-imidazolidinone, 0.7 g of 4-ethyl-3-(3-bromophenyl)-1-(3-trifluoromethylphenyl)-2-pyrrolidinone (Compound No. 25) and 1.2 g of cuprous cyanide were added. After the resultant mixture was stirred at 160° C. for 4 hours, the insoluble matter was filtered off from the reaction mixture and the filtrate was poured into water, followed by extraction with toluene. The extract was dried over anhydrous sodium sulfate, concentrated in an evaporator, and then purified by chromatography on a silica gel column, whereby 0.35 g of the title compound was obtained.

Provenance & Evidence