反应详情

To 0.975 grams (five millimoles) of 4-hydroxy-4'-cyanobiphenyl dissolved with 1.08 grams (5.5 millimoles) of 1-bromo 2-(2-ethoxyethoxy)-ethane in 25 mls. of acetonitrile, 1.4 grams (ten millimoles) of finely ground potassium carbonate were added. The reaction mixture was refluxed overnight. Thin layer chromatographic analysis indicated total conversion. The reaction mixture was cooled and filtered and the product was washed with acetonitrile and evaporated to a white solid. The product was recrystallized from isopropanol and dried in vacuo to two grams (93% yield) of a compound having the following formula structure: ##STR22##

1. temperatureThe reaction mixture was refluxed overnight
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered
4. washthe product was washed with acetonitrile
5. customevaporated to a white solid
6. customThe product was recrystallized from isopropanol