Hydrochloric Acid → HCID 14751603, compound

HRID 654431Notes

Reaction equation

HRID 654431 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][C:3]1=[O:11].[Cl:12][CH2:13][CH2:14][C:15](Cl)=[O:16].Cl>>[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([C:15](=[O:16])[CH2:14][CH2:13][Cl:12])=[CH:10][C:5]=2[O:4][C:3]1=[O:11]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 308462-Benzoxazolinone, 3-methyl-HCID 693643-Chloropropionyl chloride

Product 1

HCID 14751603HCID 14751603, compound

Conditions

Temperature
75 °C

Procedure

The flask is equipped with a reflux condenser and taken to an oil bath at a temperature in the region of 40°-45° C. 0.04 mole of 3-methylbenzoxazolinone and 0.44 mole of 3-chloropropionic acid chloride are introduced. The mixture is heated to a temperature in the region of 75° C. for 2 hours 30 minutes. After cooling, the reaction mixture is poured into 300 g of ice, acidified with concentrated hydrochloric acid and stirred for 1 hour 30 minutes. The precipitate obtained is drained, washed with water and dried. The product is recrystallized in ethanol.

Workup

  1. customThe flask is equipped with a reflux condenser
  2. customtaken to an oil bath at a temperature in the region of 40°-45° C
  3. temperatureAfter cooling
  4. customThe precipitate obtained
  5. washwashed with water
  6. customdried
  7. customThe product is recrystallized in ethanol

Sources & evidence

ORD record
ord-5b171e8751b7410686f40ccb1488206d
Source dataset
uspto-grants-1992_07
Patent number
US05132305

Reaction notes

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