Dimethyl Sulfate → HCID 14819425, compound

HRID 654442Notes

Reaction equation

HRID 654442 reaction equation
[CH3:1][C:2]1([CH3:23])[CH:11]([OH:12])[CH:10]([O:13][C:14]2[CH:19]=[CH:18][NH:17][C:16](=[O:20])[CH:15]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:21]#[N:22])[CH:8]=2)[CH2:3]1.[C:24]([O-])([O-])=O.[K+].[K+].COS(OC)(=O)=O>CC(C)=O>[CH3:1][C:2]1([CH3:23])[CH:11]([OH:12])[CH:10]([O:13][C:14]2[CH:19]=[CH:18][N:17]([CH3:24])[C:16](=[O:20])[CH:15]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:21]#[N:22])[CH:8]=2)[CH2:3]1

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 14819424HCID 14819424, compound

Product 1

HCID 14819425HCID 14819425, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 310 mg of 2,2-dimethyl-4-(2-oxo-1,2-dihydro-4-pyridyloxy)-6-cyano-1,2,3,4-tetrahydro-3-naphthol, 20 ml of acetone, 400 mg of K2CO3 and 0.2 ml of dimethylsulfate is boiled for 2 hours. The mixture is filtered and the filtrate is worked up in the customary manner to give 2,2-dimethyl-4-(1-methyl-2-oxo-1,2-dihydro-4-pyridyloxy)-6-cyano-1,2,3,4-tetrahydro-3-naphthol.

Workup

  1. filtrationThe mixture is filtered

Sources & evidence

ORD record
ord-10a94494f98d490fb14ebc10444578e6
Source dataset
uspto-grants-1992_07
Patent number
US05132307

Reaction notes

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