反应详情

A 2.0 g amount of tetrafluoroisophthalonitrile and 0.7 g of sodium hydroxide were added to 40 ml of water and the mixture was heated under reflux for 1.5 hours. After cooling, the mixture was neutralized with concentrated hydrochloric acid and was then extracted with ether. After the ether extract was washed with water, the extract was dried with magnesium sulfate. The solvent was distilled off and the resultant crude crystal was recrystallized to obtain 1.39 g of the desired compound No. 19.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 1.5 hours
3. temperatureAfter cooling
4. extractionwas then extracted with ether
5. extractionAfter the ether extract
6. washwas washed with water
7. dry with materialthe extract was dried with magnesium sulfate
8. distillationThe solvent was distilled off
9. customthe resultant crude crystal was recrystallized