Hydrochloric Acid → HCID 13540463, compound

HRID 65452Notes

Reaction equation

HRID 65452 reaction equation
[F:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([F:10])[C:5]([C:11]#[N:12])=[C:4](F)[C:3]=1[F:14].[OH-:15].[Na+].Cl>O>[F:10][C:6]1[C:7]([C:8]#[N:9])=[C:2]([F:1])[C:3]([F:14])=[C:4]([OH:15])[C:5]=1[C:11]#[N:12]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 608182Tetrafluoroisophthalonitrile

Product 1

HCID 13540463HCID 13540463, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A 2.0 g amount of tetrafluoroisophthalonitrile and 0.7 g of sodium hydroxide were added to 40 ml of water and the mixture was heated under reflux for 1.5 hours. After cooling, the mixture was neutralized with concentrated hydrochloric acid and was then extracted with ether. After the ether extract was washed with water, the extract was dried with magnesium sulfate. The solvent was distilled off and the resultant crude crystal was recrystallized to obtain 1.39 g of the desired compound No. 19.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 1.5 hours
  3. temperatureAfter cooling
  4. extractionwas then extracted with ether
  5. extractionAfter the ether extract
  6. washwas washed with water
  7. dry with materialthe extract was dried with magnesium sulfate
  8. distillationThe solvent was distilled off
  9. customthe resultant crude crystal was recrystallized

Sources & evidence

ORD record
ord-787b28e2af144e7ca05d638f761c7178
Source dataset
uspto-grants-1986_09
Patent number
US04614742

Reaction notes

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