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HRID654544

反应详情

EQUATION

反应方程式

HRID 654544 的结构方程式

REACTANTS

反应物

5
结构：CCB(CC)CC
HCID7357

Triethylborane

C6H15B

结构：COC(=O)CC(C)=O
HCID7757

Methyl acetoacetate

C5H8O3

结构：CC(C)[N-]C(C)C.[Li+]
HCID2724682

2-Propanamine, N-(1-methylethyl)-, lithium salt

C6H14LiN

结构：[BH4-].[Na+]
HCID4311764

Sodium borohydride (Na(BH4))

H4BNa

结构：CC=C=O.Cc1cc(C2=CC(C)(C)CC(N3CCCC3)C2)ccc1F
HCID86746001

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)CC(O)CC(O)/C=C/C1=C(c2ccc(F)c(C)c2)CC(N2CCCC2)CC1(C)C
HCID86744089

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

In a manner similar to Scheme I, 33 (2.27 g, 6,65 mmol) was treated with the LDA derived anion of methyl acetoacetate (7.98 mmol) followed by triethylborane, methanol, and NaBH4. Workup and purification by HPLC using 1% Et3N in EtOAc as eluent provided the oily product.

WORKUP

后处理

  1. customWorkup and purification by HPLC
  2. customprovided the oily product