2-Bromomethylnaphthalene → HCID 19761561, compound

HRID 654555Notes

Reaction equation

[OH:1][C:2]1[CH:3]=[C:4]([C:8]([O:15][CH3:16])([CH2:12][O:13][CH3:14])[CH2:9][CH2:10][OH:11])[CH:5]=[CH:6][CH:7]=1.Br[CH2:18][C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=1>>[CH3:16][O:15][C:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([O:1][CH2:18][C:19]2[CH:28]=[CH:27][C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH:20]=2)[CH:3]=1)([CH2:12][O:13][CH3:14])[CH2:9][CH2:10][OH:11]

Participants

Reactant 2

HCID 703202-Bromomethylnaphthalene

HCID 19761550HCID 19761550, compound

Product 1

HCID 19761561HCID 19761561, compoundYield 87%

Procedure

Using the procedure described in Example 12, 3-(3-hydroxyphenyl)-3,4-dimethoxybutan-1-ol was reacted with 2-bromomethylnaphthalene to give 3,4-dimethoxy-3-[3-(naphth-2-ylmethoxy)phenyl]butan-1-ol in 87% yield, m.p. 64°-65° C.

Sources & evidence

ORD record: ord-58038e5c3e704759bc3c420b54829d39
Source dataset: uspto-grants-1992_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05132328

Reaction notes

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