2-(5-Fluoro-3-hydroxyphenyl)-2-methoxybut-1-yl methyl ether → 2-[5-Fluoro-3-(7-fluoronaphth-2-ylmethoxy)phenyl]-2-methoxybut-1-yl methyl ether

HRID 654560Notes

Reaction equation

HRID 654560 reaction equation
[CH3:1][O:2][CH2:3][C:4]([C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[C:11]([OH:16])[CH:10]=1)([O:7][CH3:8])[CH2:5][CH3:6].Br[CH2:18][C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][C:23]([F:29])=[CH:24][CH:25]=2)[CH:20]=1>>[CH3:1][O:2][CH2:3][C:4]([C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[C:11]([O:16][CH2:18][C:19]2[CH:28]=[CH:27][C:26]3[C:21](=[CH:22][C:23]([F:29])=[CH:24][CH:25]=3)[CH:20]=2)[CH:10]=1)([O:7][CH3:8])[CH2:5][CH3:6]

Participants

3

Reactant 2

HCID 197615172-(5-Fluoro-3-hydroxyphenyl)-2-methoxybut-1-yl methyl etherHCID 232922952-(Bromomethyl)-7-fluoronaphthalene

Product 1

HCID 197615092-[5-Fluoro-3-(7-fluoronaphth-2-ylmethoxy)phenyl]-2-methoxybut-1-yl methyl etherYield 76%

Procedure

Using the procedure described in Example 12, 2-(5-fluoro-3-hydroxyphenyl)-2-methoxybut-1-yl methyl ether was reacted with 2-bromomethyl-7-fluoronaphthalene to give 2-[5-fluoro-3-(7-fluoronaphth-2-ylmethoxy)phenyl]-2-methoxybut-1-yl methyl ether in 76% yield, as an oil.

Sources & evidence

ORD record
ord-459fcba4c14e4e0e98215f4185ad6f19
Source dataset
uspto-grants-1992_07
Patent number
US05132328

Reaction notes

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