Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 654560Generated: October 30, 2026

2-(5-Fluoro-3-hydroxyphenyl)-2-methoxybut-1-yl methyl ether → 2-[5-Fluoro-3-(7-fluoronaphth-2-ylmethoxy)phenyl]-2-methoxybut-1-yl methyl ether

https://huagongshe.com/reaction/654560

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(5-Fluoro-3-hydroxyphenyl)-2-methoxybut-1-yl methyl etherHCID 19761517—
Reactant2-(Bromomethyl)-7-fluoronaphthaleneHCID 23292295—
Product2-[5-Fluoro-3-(7-fluoronaphth-2-ylmethoxy)phenyl]-2-methoxybut-1-yl methyl etherHCID 1976150976%

Reaction Steps

Using the procedure described in Example 12, 2-(5-fluoro-3-hydroxyphenyl)-2-methoxybut-1-yl methyl ether was reacted with 2-bromomethyl-7-fluoronaphthalene to give 2-[5-fluoro-3-(7-fluoronaphth-2-ylmethoxy)phenyl]-2-methoxybut-1-yl methyl ether in 76% yield, as an oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05132328
Source datasetuspto-grants-1992_07
ORD IDord-459fcba4c14e4e0e98215f4185ad6f19
Source noteuspto-grants-1992_07