2-Bromomethylnaphthalene → HCID 19761513, compound

HRID 654561Notes

Reaction equation

[CH3:1][O:2][CH2:3][C:4]([C:9]1[CH:10]=[N:11][CH:12]=[C:13]([OH:15])[CH:14]=1)([O:7][CH3:8])[CH2:5][CH3:6].Br[CH2:17][C:18]1[CH:27]=[CH:26][C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=1>>[CH3:1][O:2][CH2:3][C:4]([O:7][CH3:8])([C:9]1[CH:10]=[N:11][CH:12]=[C:13]([O:15][CH2:17][C:18]2[CH:27]=[CH:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=2)[CH:14]=1)[CH2:5][CH3:6]

Participants

Reactant 2

HCID 703202-Bromomethylnaphthalene

HCID 19761514HCID 19761514, compound

Product 1

HCID 19761513HCID 19761513, compoundYield 37.2%

Procedure

Using the procedure described in Example 12, 2-(5-hydroxypyrid-3-yl)-2-methoxybut-1-yl methyl ether (0.21 g) was reacted with 2-bromomethylnaphthalene (0.25 g) to give 2-methoxy-2-[5-(naphth-2-ylmethoxy)pyrid-3-yl]but-1-yl methyl ether (0.13 g, 37%), as an oil.

Sources & evidence

ORD record: ord-aa99093c33514514bf3bf58140938a7d
Source dataset: uspto-grants-1992_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05132328

Reaction notes

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