反应详情

A 2.0 g amount of tetrafluoroisophthalonitrile and 0.87 g of potassium fluoride were dissolved in 10 ml of acetonitrile. After cooling to a temperature of 0° C., 0.90 g (1.04 ml) of n-butylmercaptan was gradually dropwise added to the mixture and the resultant mixture was stirred at a temperature of 0° C. or less for 12 hours. After 50 ml of water was added to the reaction mixture, the reaction mixture was extracted with chloroform and the extract was then washed with a saturated aqueous sodium bicarbonate solution, followed by drying with anhydrous magnesium sulfate. After distilling off the chloroform, the resultant crude product was distilled in vacuo. Thus, 2.08 g (77% yield) of the desired compound No. 52 was obtained.

1. additionwas gradually dropwise added to the mixture
2. extractionthe reaction mixture was extracted with chloroform
3. washthe extract was then washed with a saturated aqueous sodium bicarbonate solution
4. dry with materialby drying with anhydrous magnesium sulfate
5. distillationAfter distilling off the chloroform
6. distillationthe resultant crude product was distilled in vacuo