3-Chloro-1-propyne → 2,3,5,6-Tetrafluoro-4-(2-propyn-1-yl)benzyl Alcohol

HRID 654616Notes

Reaction equation

HRID 654616 reaction equation
Br[C:2]1[C:15]([F:16])=[C:14]([F:17])[C:5]([CH2:6][O:7]C2CCCCO2)=[C:4]([F:18])[C:3]=1[F:19].[CH2:20](Cl)[C:21]#[CH:22]>>[CH2:22]([C:2]1[C:3]([F:19])=[C:4]([F:18])[C:5]([CH2:6][OH:7])=[C:14]([F:17])[C:15]=1[F:16])[C:21]#[CH:20]

Participants

3

Reactant 2

HCID 122213-Chloro-1-propyneHCID 136705722-[(4-Bromo-2,3,5,6-tetrafluorophenyl)methoxy]tetrahydro-2H-pyran

Product 1

HCID 114359092,3,5,6-Tetrafluoro-4-(2-propyn-1-yl)benzyl Alcohol

Procedure

4-(Prop-2-yn-1-yl)-2,3,5,6-tetrafluorobenzyl alcohol was prepared from 2-[4-bromo-2,3,5,6-tetrafluorobenzyloxy)-tetrahydropyran and propargyl chloride, by a two stage procedure similar to that described in Example 4.

Sources & evidence

ORD record
ord-5ce9533c29f84242b8341dbcdb65a59f
Source dataset
uspto-grants-1992_07
Patent number
US05132469

Reaction notes

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