HCID 19742171, compound → HCID 19742173, compound

HRID 654632Notes

Reaction equation

HRID 654632 reaction equation
[CH2:1]([N:5]1[C:9]2([CH2:14][O:13][P:12](Cl)[O:11][CH2:10]2)[CH2:8][O:7][P:6]1Cl)[CH:2]([CH3:4])[CH3:3].[C:17]1([Mg]Cl)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>O1CCCC1>[CH2:1]([N:5]1[C:9]2([CH2:14][O:13][P:12]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[O:11][CH2:10]2)[CH2:8][O:7][P:6]1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH:2]([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 19742171HCID 19742171, compound2×HCID 178478979HCID 178478979, compound

Product 1

HCID 19742173HCID 19742173, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Into a solution of 10.0 g (32.7 mmol) of 1-isobutyl-2,8-dichloro-3,7,9-trioxa-1-aza-2,8-diphosphaspiro[4.5]decane, the compound of Example 8, in 60 mL of tetrahydrofuran (THF) is added dropwise 32.7 mL (65.4 mmol) of a 2M solution of phenyl magnesium chloride in THF at ambient temperature. The title compound is isolated in a yield of 11 g as an oil and identified by mass spectrometry: m/z=389.

Sources & evidence

ORD record
ord-28e5425f390f4a5c9a25b27a269bb70c
Source dataset
uspto-grants-1992_07
Patent number
US05132426

Reaction notes

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