反应详情

18 g of 4-hydroxy-5-methyl-1-naphthalenecarbaldehyde and 15 g of N,N-diisopropylethylamine were dissolved in 200 ml of dichloromethane, in which 9.3 g of chloromethyl methyl ether was gradually dropped under ice-cooling conditions. After agitation at room temperature overnight, the reaction solution was washed with water and dried with anhydrous magnesium sulfate. The solvent was distilled off and the residue was purified by silica gel column chromatography (10% ethyl acetate/hexane) to obtain 16.8 g of the captioned compound as light brown crystals.

1. additionwas gradually dropped under ice-
2. temperaturecooling conditions
3. washAfter agitation at room temperature overnight, the reaction solution was washed with water
4. dry with materialdried with anhydrous magnesium sulfate
5. distillationThe solvent was distilled off
6. customthe residue was purified by silica gel column chromatography (10% ethyl acetate/hexane)