Water → HCID 9972006, compound

HRID 654716Notes

Reaction equation

HRID 654716 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5](/[CH:20]=[C:21](/[CH3:25])\[C:22]([OH:24])=[O:23])[C:6]2[C:11]([C:12]=1[O:13]COC)=[C:10]([CH2:17][CH2:18][CH3:19])[CH:9]=[CH:8][CH:7]=2.O>CC(C)=O.Cl>[OH:13][C:12]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[CH2:17][CH2:18][CH3:19])[C:5](/[CH:20]=[C:21](/[CH3:25])\[C:22]([OH:24])=[O:23])=[CH:4][C:3]=1[O:2][CH3:1]

Participants

5

Reactant 2

HCID 962WaterHCID 9974775HCID 9974775, compound

Product 1

HCID 9972006HCID 9972006, compoundYield 88.6%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 313Hydrochloric AcidSolvent

Procedure

2.2 g of (Z)-3-(3-methoxy-4-methoxymethoxy-5-propyl-1-naphthyl)-2-methylpropenoic acid was dissolved in 40 ml of acetone, to which 2.5 ml of concentrated hydrochloric acid was added under light-shielding conditions, followed by stirring in a stream of nitrogen at room temperature for 2 hours. The reaction mixture was poured into water, and the resultant crystals were filtered, washed with hexane and dried in vacuo to obtain 1.7 g of the titled compound as yellow crystals.

Workup

  1. additionwas added under light-shielding conditions
  2. filtrationthe resultant crystals were filtered
  3. washwashed with hexane
  4. customdried in vacuo

Sources & evidence

ORD record
ord-48de4f8a8dd242e0a6da4ae57e13f389
Source dataset
uspto-grants-1992_07
Patent number
US05134111

Reaction notes

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