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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 654747Generated: October 26, 2026

1-Acetyl-4-(2',4'-difluorobenzoyl)piperidine → (2,4-Difluorophenyl)(piperidin-4-yl)methanone

https://huagongshe.com/reaction/654747

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Acetyl-4-(2',4'-difluorobenzoyl)piperidineHCID 2740707—
SolventHydrochloric AcidHCID 313—
Product(2,4-Difluorophenyl)(piperidin-4-yl)methanoneHCID 1307638883%

Reaction Steps

30 g of 1-acetyl-4-(2,4-difluorobenzoyl)piperidine are brought to reflux in 113 ml of 6N hydrochloric acid for 6 hours. The reaction medium is then concentrated and the residue obtained is crystallized in isopropanol. The expected compound is isolated after filtration.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05134147
Source datasetuspto-grants-1992_07
ORD IDord-78688ab8dc6643f68661df2a75944e16
Source noteuspto-grants-1992_07