1-Acetyl-4-(2',4'-difluorobenzoyl)piperidine → (2,4-Difluorophenyl)(piperidin-4-yl)methanone

HRID 654747Notes

Reaction equation

HRID 654747 reaction equation
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10](=[O:19])[C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=2[F:18])[CH2:6][CH2:5]1)(=O)C>Cl>[F:18][C:12]1[CH:13]=[C:14]([F:17])[CH:15]=[CH:16][C:11]=1[C:10]([CH:7]1[CH2:6][CH2:5][NH:4][CH2:9][CH2:8]1)=[O:19]

Participants

3

Reactant 1

HCID 27407071-Acetyl-4-(2',4'-difluorobenzoyl)piperidine

Product 1

HCID 13076388(2,4-Difluorophenyl)(piperidin-4-yl)methanoneYield 83%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

30 g of 1-acetyl-4-(2,4-difluorobenzoyl)piperidine are brought to reflux in 113 ml of 6N hydrochloric acid for 6 hours. The reaction medium is then concentrated and the residue obtained is crystallized in isopropanol. The expected compound is isolated after filtration.

Workup

  1. concentrationThe reaction medium is then concentrated
  2. customthe residue obtained
  3. customis crystallized in isopropanol

Sources & evidence

ORD record
ord-78688ab8dc6643f68661df2a75944e16
Source dataset
uspto-grants-1992_07
Patent number
US05134147

Reaction notes

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