Hydrochloric Acid → HCID 19886232, compound

HRID 654776Notes

Reaction equation

HRID 654776 reaction equation
[N:1]([O-])=O.[Na+].[F:5][C:6]1[CH:12]=[CH:11][C:9]([NH2:10])=[C:8]([N+:13]([O-:15])=[O:14])[CH:7]=1.[ClH:16]>O>[ClH:16].[F:5][C:6]1[CH:12]=[CH:11][C:9]([NH:10][NH2:1])=[C:8]([N+:13]([O-:15])=[O:14])[CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric Acid2×HCID 677694-Fluoro-2-nitroanilineHCID 23668193Sodium Nitrite

Product 1

HCID 19886232HCID 19886232, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

A solution of sodium nitrite (3.6 g) in water (18 ml) was added dropwise to an ice-salt cooled solution of 4-fluoro-2-nitroaniline 7 g) in conc. hydrochloric acid (45 ml) over a 30 minutes interval. The mixture was stirred at 0° C. for 30 minutes. Then to the mixture was added dropwise a solution of stannous chloride dihydrate (28.6 g) in conc. hydrochloric acid (24 ml) below 5° C. over an hour interval. The precipitates were collected by filtration and washed with ether to give crystals of 4-fluoro-2-nitrophenylhydrazine hydrochloride 4.4 g).

Workup

  1. filtrationThe precipitates were collected by filtration
  2. washwashed with ether

Sources & evidence

ORD record
ord-c6fd692c8ee04dc4b0fdb10aa637d3ec
Source dataset
uspto-grants-1992_07
Patent number
US05134142

Reaction notes

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