Thionyl Chloride → HCID 11791912, compound

HRID 654791Notes

Reaction equation

HRID 654791 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([S:19][CH3:20])=[CH:15][CH:14]=3)=[CH:11][C:10]([C:21]([OH:23])=O)=[N:9]2)=[CH:4][CH:3]=1.S(Cl)([Cl:26])=O>ClC(Cl)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([S:19][CH3:20])=[CH:15][CH:14]=3)=[CH:11][C:10]([C:21]([Cl:26])=[O:23])=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 10782496HCID 10782496, compound

Product 1

HCID 11791912HCID 11791912, compound

Reagents, catalysts & solvents 1

HCID 63651,1-DichloroethaneSolvent

Procedure

A mixture of 1-(4-fluorophenyl)-5-[4-(methylthio)phenyl]pyrazole-3-carboxylic acid (13.5 g) and thionyl chloride (10 ml) in dichloroethane (30 ml) was refluxed for 1 hour. The mixture was concentrated to give an oil of 1-(4-fluorophenyl)-5-[4-(methylthio)phenyl]pyrazole-3-carbonyl chloride.

Workup

  1. temperaturewas refluxed for 1 hour
  2. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-0a78bff5cb7c4ba8abd600a8b26ba007
Source dataset
uspto-grants-1992_07
Patent number
US05134142

Reaction notes

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