Formamide → HCID 19886242, compound

HRID 654798Notes

Reaction equation

HRID 654798 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[S:14][C:15]([S:18][CH3:19])=[CH:16][CH:17]=3)=[CH:11][C:10]([C:20]([O:22]CC)=O)=[N:9]2)=[CH:4][CH:3]=1.C[O-].[Na+].O.C([NH2:31])=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[S:14][C:15]([S:18][CH3:19])=[CH:16][CH:17]=3)=[CH:11][C:10]([C:20]([NH2:31])=[O:22])=[N:9]2)=[CH:4][CH:3]=1

Participants

5

Reactant 4

HCID 713FormamideHCID 962WaterHCID 10594824Ethyl 1-(4-fluorophenyl)-5-[5-(methylthio)-2-thienyl]pyrazole-3-carboxylateHCID 10942334Sodium Methoxide

Product 1

HCID 19886242HCID 19886242, compound

Conditions

Temperature
100 °C

Procedure

A mixture of ethyl 1-(4-fluorophenyl)-5-[5-(methylthio)-2-thienyl]pyrazole-3-carboxylate (2.1 g) and sodium methoxide (895 mg) in formamide (10 ml) was stirred at 100° C. for 1 hour. Water was added to the reaction mixture, and the precipitates were collected, washed with water, and dried invacuo to give crystals of 1-(4-fluorophenyl)-5-[5-(methylthio)-2-thienyl]pyrazole-3-carboxamide (1.6 g).

Workup

  1. customthe precipitates were collected
  2. washwashed with water
  3. customdried invacuo

Sources & evidence

ORD record
ord-8f16b20141254e24aff61e5148e156f9
Source dataset
uspto-grants-1992_07
Patent number
US05134142

Reaction notes

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