反应详情

温度

100 °C

A mixture of ethyl 1-(4-fluorophenyl)-5-[5-(methylthio)-2-thienyl]pyrazole-3-carboxylate (2.1 g) and sodium methoxide (895 mg) in formamide (10 ml) was stirred at 100° C. for 1 hour. Water was added to the reaction mixture, and the precipitates were collected, washed with water, and dried invacuo to give crystals of 1-(4-fluorophenyl)-5-[5-(methylthio)-2-thienyl]pyrazole-3-carboxamide (1.6 g).

1. customthe precipitates were collected
2. washwashed with water
3. customdried invacuo