Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl 1-(4-fluorophenyl)-5-[5-(methylthio)-2-thienyl]pyrazole-3-carboxylate | HCID 10594824 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Product | HCID 19886242 | HCID 19886242 | — |
Reaction Steps
A mixture of ethyl 1-(4-fluorophenyl)-5-[5-(methylthio)-2-thienyl]pyrazole-3-carboxylate (2.1 g) and sodium methoxide (895 mg) in formamide (10 ml) was stirred at 100° C. for 1 hour. Water was added to the reaction mixture, and the precipitates were collected, washed with water, and dried invacuo to give crystals of 1-(4-fluorophenyl)-5-[5-(methylthio)-2-thienyl]pyrazole-3-carboxamide (1.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05134142 |
|---|
| Source dataset | uspto-grants-1992_07 |
|---|
| ORD ID | ord-8f16b20141254e24aff61e5148e156f9 |
|---|
| Source note | uspto-grants-1992_07 |
|---|
