2-(2,4-difluorophenyl)-4-(methanesulfonyloxy)-4-methyl-(1H-1,2,4-triazol-1-yl)-2-butanol → HCID 15008578, compound

HRID 654851Notes

Reaction equation

HRID 654851 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:24])([CH2:16][CH:17](OS(C)(=O)=O)[CH3:18])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1.C([Mg]Cl)C=C>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1([CH2:10][N:11]2[CH:15]=[N:14][CH:13]=[N:12]2)[CH2:16][CH:17]([CH3:18])[O:24]1

Participants

3

Reactant 2

HCID 198865092-(2,4-difluorophenyl)-4-(methanesulfonyloxy)-4-methyl-(1H-1,2,4-triazol-1-yl)-2-butanolHCID 178418473HCID 178418473, compound

Product 1

HCID 15008578HCID 15008578, compound

Procedure

Following a procedure similar to that described in Example 4, but using 590 mg of 2-(2,4-difluorophenyl)-4-(methanesulfonyloxy)-4-methyl-(1H-1,2,4-triazol-1-yl)-2-butanol (which was synthesized from allylmagnesium chloride in a similar manner to the procedure described in Japanese Patent Provisional Publication No. Sho 59-517 and Preparations 2, 3 and 4), one of the stereoisomers at the C4 position was obtained as the major product in the form of an oil.

Workup

  1. customSho 59-517 and Preparations 2, 3 and 4), one of the stereoisomers at the C4 position was obtained as the major product in the form of an oil

Sources & evidence

ORD record
ord-9405083c0f204477b11eb08fc4557b76
Source dataset
uspto-grants-1992_07
Patent number
US05134152

Reaction notes

Loading…