2,3-Dimethyl-2-butene → 2-(2,4'-Difluorophenyl)-3,3,4,4-tetramethyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxetane

HRID 654857Notes

Reaction equation

HRID 654857 reaction equation
[CH3:1][C:2](=[C:4]([CH3:6])[CH3:5])[CH3:3].[F:7][C:8]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:9]=1[C:15](=[O:22])[CH2:16][N:17]1[CH:21]=[N:20][CH:19]=[N:18]1>>[F:7][C:8]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:9]=1[C:15]1([CH2:16][N:17]2[CH:21]=[N:20][CH:19]=[N:18]2)[C:4]([CH3:6])([CH3:5])[C:2]([CH3:3])([CH3:1])[O:22]1

Participants

3

Reactant 2

HCID 112502,3-Dimethyl-2-buteneHCID 5880801-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

Product 1

HCID 150086152-(2,4'-Difluorophenyl)-3,3,4,4-tetramethyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxetaneYield 15%

Procedure

Following a procedure similar to that described in Example 39, but using 2,3-dimethyl-2-butene and 2',4'-difluoro-2-(1H-1,2,4-triazol-1-yl)acetophenone, 85 mg (yield 15%) of the title compound, melting at 100°-101° C., were obtained.

Sources & evidence

ORD record
ord-bc2aaa7144b24cb3848d25e8837f2293
Source dataset
uspto-grants-1992_07
Patent number
US05134152

Reaction notes

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