Oxalic Acid → HCID 67793337, compound

HRID 654864Notes

Reaction equation

HRID 654864 reaction equation
[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2([CH2:20][N:21]3[CH:25]=[N:24][CH:23]=[N:22]3)[CH:17]([CH3:18])[CH:16]([CH3:19])[O:15]2)=[CH:10][CH:9]=1>C(OCC)(=O)C>[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[Cl:7][C:8]1[CH:9]=[CH:10][C:11]([C@@:14]2([CH2:20][N:21]3[CH:25]=[N:24][CH:23]=[N:22]3)[C@@H:17]([CH3:18])[C@@H:16]([CH3:19])[O:15]2)=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 971Oxalic AcidHCID 15008566HCID 15008566, compound

Product 1

HCID 67793337HCID 67793337, compoundYield 57.7%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A solution of 97.2 ml of oxalic acid in ethyl acetate was added dropwise to a solution of 300 mg (1.08 mmole) of 2R*, 3S*, 4R*)-2-(4-chlorophenyl)-3,4-dimethyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxetane (prepared as described in Example 20) in 5 ml of ethyl acetate, and the crystals which precipitated were collected by filtration. After drying, there were obtained 229 mg (yield 57.7%) of the title compound, melting at 135°-144° C.

Workup

  1. customthe crystals which precipitated
  2. filtrationwere collected by filtration
  3. customAfter drying

Sources & evidence

ORD record
ord-5bfcfa3b06744e3494c7e12cc41150b9
Source dataset
uspto-grants-1992_07
Patent number
US05134152

Reaction notes

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