Hydrochloric Acid → HCID 85526988, compound

HRID 65488Notes

Reaction equation

HRID 65488 reaction equation
[C:1]1([CH2:7][CH:8]=[N:9][OH:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.ClCl.ClC1(CC=NO)C=CC=CC1.[CH3:24][C:25]([CH3:28])([O-:27])[CH3:26].[K+].Cl>C(Cl)(Cl)Cl.C(O)(C)(C)C>[C:25]([O:27][C:8](=[N:9][OH:10])[CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)([CH3:28])([CH3:26])[CH3:24]

Participants

8

Reactant 5

HCID 313Hydrochloric AcidHCID 24526ChlorineHCID 99748PhenylacetaldoximeHCID 23665647Potassium tert-butoxide2×HCID 867410451-Chlorophenyl acetaldehyde oxime

Product 1

HCID 85526988HCID 85526988, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 6386tert-ButanolSolvent

Procedure

Using the procedure of Example I, phenyl acetaldehyde oxime in chloroform is reacted with chlorine gas introduced at -5° to 0° C. To the resulting solution of 1-chlorophenyl acetaldehyde oxime is added dropwise with stirring a solution of potassium t-butoxide in t-butanol. The reaction is allowed to go to completion and any residual potassium t-butoxide is neutralized with hydrogen chloride gas. The precipitated potassium chloride is removed by filtration, and the filtrate concentrated under reduced pressure to provide the desired 1-(t-butoxy)-2-phenyl acetaldehyde oxime.

Workup

  1. additionintroduced at -5° to 0° C
  2. customThe precipitated potassium chloride is removed by filtration
  3. concentrationthe filtrate concentrated under reduced pressure

Sources & evidence

ORD record
ord-4877adffe60f4315972688612a661cb9
Source dataset
uspto-grants-1986_09
Patent number
US04614813

Reaction notes

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