反应详情

Sodium borohydride (1.89 g; 50 mmole) was added to methanol (20 ml), and the solution was heated under reflux for 10 minutes and then allowed to cool to room temperature. p-Nitrobenzyl 3-oxo-5-benzyloxy-4-methylpentanoate (3.7 g; 10 mmole) was dropwise added thereto, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was diluted with ethyl acetate and washed with dilute hydrochloric acid and an aqueous solution of sodium chloride and dried over anhydrous sodium sulfate. After removal of the solvent under reduced pressure, the residue was purified by silica gel column chromatography to give methyl 3-oxo-5-benzyloxy-4-methylpentanoate.

1. temperaturethe solution was heated
2. temperatureunder reflux for 10 minutes
3. washwashed with dilute hydrochloric acid
4. dry with materialan aqueous solution of sodium chloride and dried over anhydrous sodium sulfate
5. customAfter removal of the solvent under reduced pressure
6. customthe residue was purified by silica gel column chromatography