反应详情

Methyl (S)-(+)-2-methyl-3-hydroxypropionate (2.36 g; 20 mmole) was dissolved in dry dichloromethane (30 ml), conc. sulfuric acid (0.2 ml) was added thereto, and isobutene (23.5 g) was introduced into the resultant mixture kept at -60° to -70° C., followed by stirring at room temperature for 3 hours. The reaction mixture was sealed and stirred overnight, and unreacted isobutene was removed therefrom by distillation. The mixture was washed successively with water and a saturated sodium bicarbonate solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give methyl (S)-3-t-butoxy-2-methylpropionate.

1. customkept at -60° to -70° C.
2. customThe reaction mixture was sealed
3. stirringstirred overnight
4. customunreacted isobutene was removed
5. distillationby distillation
6. washThe mixture was washed successively with water
7. dry with materiala saturated sodium bicarbonate solution, dried over anhydrous sodium sulfate
8. concentrationconcentrated under reduced pressure