Sulfuric Acid → methyl (S)-3-t-butoxy-2-methylpropionate

참여 물질

반응 단계

Methyl (S)-(+)-2-methyl-3-hydroxypropionate (2.36 g; 20 mmole) was dissolved in dry dichloromethane (30 ml), conc. sulfuric acid (0.2 ml) was added thereto, and isobutene (23.5 g) was introduced into the resultant mixture kept at -60° to -70° C., followed by stirring at room temperature for 3 hours. The reaction mixture was sealed and stirred overnight, and unreacted isobutene was removed therefrom by distillation. The mixture was washed successively with water and a saturated sodium bicarbonate solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give methyl (S)-3-t-butoxy-2-methylpropionate.

출처 및 근거