Methyl iodide → HCID 178457298, compound

HRID 654995Notes

Reaction equation

HRID 654995 reaction equation
[H-].[Na+].[C:3]([C:6](=[C:11]([NH:17][CH2:18][CH:19]=[CH2:20])[CH2:12][C:13]([O:15][CH3:16])=[O:14])[C:7]([O:9][CH3:10])=[O:8])(=[O:5])[CH3:4].[CH3:21]I>>[C:3]([C:6](=[C:11]([NH:17][CH2:18][CH:19]=[CH2:20])[CH:12]([CH3:21])[C:13]([O:15][CH3:16])=[O:14])[C:7]([O:9][CH3:10])=[O:8])(=[O:5])[CH3:4]

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 178457337HCID 178457337, compound

Product 1

HCID 178457298HCID 178457298, compound

Procedure

In the same manner as in Reference Example 4-2-(1) but using 60 % sodium hydride (0.8 g; 20 mmole), dimethyl 2-acetyl-3-allylamino-2-pentenedioate (2.55 g; 10 mmole) and methyl iodide (2.84 g; 20 mmole), there was produced dimethyl 2-acetyl-3-allylamino-4-methyl-2-pentenedioate.

Sources & evidence

ORD record
ord-e8fc2acf19bc4091ad0fbea1f6519fc6
Source dataset
uspto-grants-1992_07
Patent number
US05134231

Reaction notes

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