Methyl iodide → HCID 178471721, compound

HRID 654996Notes

Reaction equation

[H-].[Na+].[C:3]([C:6](=[C:12]([NH:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:7]([O:9][CH2:10][CH3:11])=[O:8])(=[O:5])[CH3:4].[CH3:27]I>>[C:3]([C:6](=[C:12]([NH:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[CH:13]([CH3:27])[C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:7]([O:9][CH2:10][CH3:11])=[O:8])(=[O:5])[CH3:4]

Participants

Reactant 3

HCID 6328Methyl iodide

HCID 24758Sodium hydride

HCID 178471978HCID 178471978, compound

Product 1

HCID 178471721HCID 178471721, compound

Procedure

In the same manner as in Reference Example 4-2-(1) but using 60 % sodium hydride (88 mg; 2.2 mmole), diethyl 2-acetyl-3-benzylamino-2-pentenedioate (333 mg; 1 mmole) and methyl iodide (156 mg; 1.1 mmole), there was produced diethyl 2-acetyl-3-benzylamino-4-methyl-2-pentenedioate.

Sources & evidence

ORD record: ord-f400e73637b5493e8db80b72d0ef0b31
Source dataset: uspto-grants-1992_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05134231

Reaction notes

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