HCID 86746016, compound → HCID 17996247, compound

HRID 655000Notes

Reaction equation

HRID 655000 reaction equation
[OH:1][CH:2]([CH:4]([CH:10]([NH:23]CC1C=CC=CC=1)[CH:11]([CH3:22])[C:12]([O:14][CH2:15][C:16]1C=CC=CC=1)=[O:13])[C:5]([O:7]CC)=[O:6])[CH3:3]>CO.[OH-].[Pd+2].[OH-].[C]>[OH:1][CH:2]([CH:4]([CH:10]([NH2:23])[CH:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH3:22])[C:5]([OH:7])=[O:6])[CH3:3]

Participants

4

Reactant 1

HCID 86746016HCID 86746016, compound

Product 1

HCID 17996247HCID 17996247, compound

Reagents, catalysts & solvents 2

HCID 178502593HCID 178502593, compoundCatalystHCID 887MethanolSolvent

Procedure

Ethyl benzyl (2SR,3RS,4RS)-2-[1(SR)-hydroxyethyl]-3-benzylamino-4-methylpentanedioate (509 mg) was dissolved in methanol (5 ml), and palladium hydroxide-carbon (102 mg) was added thereto, followed by shaking at room temperature under hydrogen atmosphere (3 to 4 kg/cm2). After consumption of the designed amount of hydrogen, the catalyst was removed by filtration. The filtrate was concentrated under reduced pressure to give (2SR,3RS,4RS)-2-[1(SR)-hydroxyethyl]-3-amino-4-ethoxycarbonylpentanoic acid.

Workup

  1. customAfter consumption of the designed amount of hydrogen
  2. customthe catalyst was removed by filtration
  3. concentrationThe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-b5ee15d9c35543e19cfbd5d87365f371
Source dataset
uspto-grants-1992_07
Patent number
US05134231

Reaction notes

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