HCID 86746016, compound → HCID 17996247, compound

Participants

Reaction Steps

Ethyl benzyl (2SR,3RS,4RS)-2-[1(SR)-hydroxyethyl]-3-benzylamino-4-methylpentanedioate (509 mg) was dissolved in methanol (5 ml), and palladium hydroxide-carbon (102 mg) was added thereto, followed by shaking at room temperature under hydrogen atmosphere (3 to 4 kg/cm2). After consumption of the designed amount of hydrogen, the catalyst was removed by filtration. The filtrate was concentrated under reduced pressure to give (2SR,3RS,4RS)-2-[1(SR)-hydroxyethyl]-3-amino-4-ethoxycarbonylpentanoic acid.

Provenance & Evidence